Liverpool's attention now switches away from the Europe League draw and onto the Premier League.
With 10 games remaining, and a potential 30 points up for grabs, the reds must continue to place pressure on the sides above them.
The reds are 8th, locked on points with Sunday's opponents who are one place ahead in 7th.
The weekend also sees 4th placed Man City taken on 6th placed United, whilst 5th placed West Ham take on Chelsea, currently 4 points behind Liverpool.
A win for Liverpool could keep them in with a chance of pushing closer to that elusive top 4th place.
Klopp, arriving to the press conference with a 'The Beatles' t-shirt, was asked about his involvement in Jon Flanagan's new contract.
The press also asked him whether he was interested in discussions over other players contract.
He responded confidently with
Southampton snatched a late equaliser at Anfield in October to deny Klopp his first home win, but the reds easily dispatched the Saints 6-1 away - handing them their heaviest home defeat for half a century - on the way to the League Cup final.
Southampton v Liverpool is on Sunday at 1:30pm UK time.