Liverpool will be hoping to take a huge step towards qualification from group E when they take on Genk at Anfield tonight.
The reds will move on to 9 points after 4 games if they get the victory.
Liverpool will also be hoping they don't need a fourth consecutive comeback, after trailing then ultimately winning the last 3 games.
The reds do have an important game against Manchester City at the weekend, but could still welcome back Fabinho who has sat out the last two games.
As it happened...
Mane, Robbo and Firmino rested. Joe Gomez gets the nod in midfield.
Alisson, Alexander-Arnold, Gomez, Van Dijk, Milner, Fabinho, Wijnaldum, Keita, Oxlade-Chamberlain, Salah, Origi.
Subs: Adrian, Lovren, Firmino, Mane, Lallana, Robertson, Jones.
Here's how our opponents line up tonight.
A number of Liverpool changes then.
Jordan Henderson misses out due to a bout of illness.
Gomez and Milner back in defence, they return to those positions for the second time in a week after being involved in that thrilling 5-5 game against Arsenal in the League Cup.
Liverpool could move 6 points clear of 3rd place in the group by the end of tonight (if results go as expected).
'It would be cool (to secure qualification sooner than last season). It obviously depends on the result in the other game. But for two and a half years it seems like every game we play is the most important game of our lives.'
James Milner leads out the Liverpool team at Anfield.
2' Genk flagged for offside, but it did look like Joe Gomez was keeping the Belgian forward onside.
Player was 30 yards out but a little bit of a let off there for Liverpool.
10' Trent corner is put wide by Virgil van Dijk.
Up front we have Alex Oxlade-Chamberlain occupying Firmino's central number 9 role. Salah on the right, Origi on the left.
Divock Origi playing against the side he joined at the age of 6 in 2001. He spent the next 9 years working his way through the academy there before moving to Lille as a 15 year old.
14' Origi dummies the ball, one two with Milner.
Milner crosses the ball, it takes a bounce of a Genk defender and Wijnaldum is 6 yards out and flicks it with his right boot past the keeper.
16' Long ball upfield by Genk. Sébastien Dewaest can't stretch to reach it and it's out for a Liverpool ball.
21' Origi and Milner combining quite well down that left hand side.
It's a chested ball by Divock and Milner tries a shot from distance. Beaten down by the keeper.
Free kick just on the edge of the area. Salah fouled.
34' Been plenty of driving runs from Naby Keita in this game. He's trying to impress.
Alex Oxlade-Chamberlain powering through towards goal and he's gone down. Collective hush from the crowd but he's got back up and is trying to run it off.
36' Salah running diagonally inside the area after a well timed pass from Milner.
He beats the defender and 8 yards out shoots across the face of goal.
Created a nice chance for himself there.
39' Corner comes in and it looks like it's going to be a free volley for van Dijk but he completely misses the kick.
Ball falls to Keita who twists and turns before Keita shoots wide.
And now Mo Salah hits it wide.
40' After all those chances the reds switch off and concede a corner.
In front of the Kop, the cross comes in to the near post and Samatta with a powerful header in.
43' From looking fairly comfortable, Liverpool are on the back foot a little bit.
Genk with another chance there that they stick just wide of Alisson.
Stay focused here reds!
44' Excellent work by Fabinho there and Origi is inside the area - but he drags that show well wide of the goal.
He really should have worked the keeper there.
Napoli 1-1 so far in the game v Red Bull Salzburg.
Liverpool 1-1 Genk
The reds just switched off in the final 5 minutes of that half and Genk got an equaliser from a superb header.
Wijnaldum has put the reds after a Milner cross bounced off one of the opposition defenders.
Improvement and focus required.
45 minutes to go.
Liverpool kicking towards The Kop on this freezing cold night.
49' Mane, Firmino and Lovren having an early warm up in the second half.
50' Origi shot - bit of power on that but the keeper stops it and then prevents it going out for a corner.
54' Fabinho squirts that through to Salah. He knocks it on to Alex Oxlade-Chamberlain who spins around and sticks that in the bottom corner.
Reds back in front. 2-1.
59' Salah spins and twists. He's got himself into the area but it's a poor shot. No power - did he scuff it? It rolls towards the keeper.
Could have put a nail in this game there.
As we move past the hour mark.
No changes yet on the field. In all fairness, Liverpool should be much more than one goal ahead. Salah and Origi both should have goals next to their names.
65' No goal for Alexander-Arnold yet on his 101st LFC appearance.
Milner slides a pass back to him at the edge of the area, first time shot by Trent, but it's over the crossbar.
68' Ndongala replaces Ito, who runs straight down the tunnel.
Andy Robertson about to come on for the reds.
74' Naby Keita and Alex Oxlade-Chamberlain off and replaced by Andy Robertson and Sadio Mane
82' They're in the hunt for an equaliser. Heynen there in acres of space after a ball was lifted over the Liverpool defence.
It's an important save from Heynen and a subsequent header goes over the crossbar.
Liverpool taking their eye off the ball at the end of this half as well?
Casper de Norre goes into the referee's naughty book.
Think that may be the first of the night.
89' Firmino replaces Divock Origi.
Liverpool 2-1 Genk
The reds should have had that wrapped up a lot earlier. Many good chances squandered.
But with two games left the reds are in a very good position now. 9 points from 12 and Napoli have drawn 1-1.
Liverpool are top of the group
'We didn't finish our situations off well. We had a lot of really big chances which we usually use - we didn't and we left the game open.
They scored a good goal - we had to defend better but it was a good goal. At the end if you only score 1 and they score 1 then you have work to do.
We felt the intensity. The good thing was that all the players came through. Rhythm is very important and you could see at the end of the game we didn't have that.
The aim was to win and we did that.
'Now we have to recover. Tomorrow will be a nice recovery for everyone and then we start to prepare for Man City.
'(On the Club World Cup) All the other date alternatives were not good for us, and it would have been difficult for Aston Villa too. We now have a little bit of time to think it through.