Top of the table Liverpool host Man City who sit currently in fourth place after Saturday's Premier League result.
The reds will be aiming to increase their lead over City to 9 points with a win, whilst City who face a tougher fixture list in the coming months will hope to cut the reds lead down to three.
With Chelsea and Leicester also enjoying good results in recent weeks, the reds will be aiming to keep ahead of those two challengers as well as Guardiola's men.
Jurgen Klopp returns to his traditional Premier League line-up with Dejan Lovren and Andy Robertson back in the starting eleven, and the midfield trio of Fabinho, Henderson and Wijnaldum all involved.
Liverpool: Alisson, Alexander-Arnold, van Dijk, Lovren, Robertson, Henderson, Wijnaldum, Fabinho, Mane, Salah, Firmino
Subs: Adrián, Milner, Origi, Lallana, Oxlade-Chamberlain, Keïta, Gomez
Man City: Bravo, Walker, Stones, Angelino, Luiz Roza, Gündogan, De Bruyne, Sterling, Agüero, Silva, Rodri
As it happened...
This will be Liverpool's 5th game against a team currently in the top 6 of the Premier League. The reds have won all 4 of their previous top six games this season.
For Man City however the opening fixture list has been far kinder, and this is the first time they have faced a top six side this season. They have also yet to play local rivals Manchester United.
6' It's an absolute rocket.
Fabinho receives the ball at the edge of the area and he leathers it in past Bravo. 1-0.
13' Wonderful start from LFC.
Salah heads in Mane's cross after a wonderful breakaway.
The reds lead 2-0.
30' Man City having a good spell.
Both teams chasing goals but it's City who have greater need for them.
Next goal could be pivotal.
36' Glorious chance for the reds there. Firmino with excellent control to sidestep the defender.
But then he fires over the crossbar.
Great half from the reds.
City still a danger but so are the reds.
This could be a big 3 points in the title campaign.
Back on it
52' Surely that's that.
Henderson cross and Mane heads in.
61' Henderson makes way for Milner.
Passes on the captains armband.
71' Aguero off. Jesus on.
Big task ahead.
79' Bernardo Silva destroys LFC's clean sheet. 3-1.
Ox is on for Firmino.
87' Salah makes way for Gomez.
4 mins injury time.
FT: Liverpool 3-1 City
Is this Liverpool's title to lose?