Liverpool travel to Old Trafford in a second successive weekend game between United and the reds.
Man Utd currently lead the Premier League table and with Liverpool's recent form will head into today's game as favourites.
The reds have scored just one goal from their last 90 chances in the Premier League and it required a second half tempo change to beat Aston Villa's U23 side in the 3rd Round.
The FA Cup seems pretty low on the Champions priority list but today's game does at least give an opportunity for some players to begin to rekindle some form with a very competitive set of Premier League fixtures coming up ahead.
Jurgen Klopp has not placed much focus on the domestic cup competitions since he joined the reds and the FA Cup remains a trophy he has yet to win as manager.
Can Liverpool score? Or get a result?
As it happened...
Sadio Mane and seemingly Joel Matip take a rest for this game. But Fabinho remains in defence - partnered this time by Rhys Williams.
Alisson, Alexander-Arnold, R. Williams, Fabinho, Robertson, Thiago, Wijnaldum, Milner, Jones, Salah, Firmino.
Subs: Kelleher, Mane, Oxlade-Chamberlain, Minamino, Tsimikas, Shaqiri, Origi, Phillips, N. Williams.
Will face West Ham at home in the next round.
West Ham beat Doncaster Rovers to progress in the competition.
The home side also make five changes from their last league outing. Bruno Fernandes named on the bench, with Cavani in the starting XI.
Henderson, Lindelöf, Maguire, Pogba, Cavani, Rashford, Greenwood, Shaw, Wan-Bissaka, van de Beek, McTominay
De Gea, Telles, Tuanzebe, Fernandes, Fred, Martial, James, Mata, Matić
Underway at Old Trafford.
Liverpool wearing the aqua coloured kit.
8' No major chances so far. Liverpool started brightly but United are playing much more football than they did at Anfield.
United certainly seem to have better energy levels in these early stages.
10' Greenwood collects the ball near the half way line and runs straight to goal before drilling his shot at Alisson.
14' Weak tackle by Rhys Williams creates a chance for United. Greenwood puts it wide.
18' Salah scores.
Firmino threads it through and Salah latches on and flicks over Henderson.
24' Dangerous(ish) position for a Liverpool free kick.
That's closer than some of Trent's free kicks over the past few weeks but it's just over the bar.
26' Equaliser through Mason Greenwood.
Marcus Rashford pinged a nice diagonal ball and James Milner couldn't leap high enough to it. It leaves Greenwood in space to place it past Alisson.
33' It's taken Liverpool a while but I think the players have now remembered that Harry Maguire's defending leaves a lot to be desired.
He's getting pressed a lot more now - the game is stretching at both ends.
35' Free kick to United, swung in, and Rhys Williams heads narrowly over our own crossbar.
And from the corner, free header for Pogba, who heads over.
37' Another corner goes United's way. Another outswinger from Luke Shaw and this time McTominay heads over.
40' Liverpool corner works it's way to Milner at the corner of the box, his shot goes wide.
42' Poor pass back from Trent, poor kick out from Alisson and Fabinho is forced to stretch to foul Greenwood.
United's free kick, thankfully, comes to nothing.
45' Rhys Williams slides in on Rashford, who jumps over him and eventually fashions a chance that Pogba puts wide.
Couple of poor choices made by the young Liverpool centre-back in this half.
Man United 1-1 Liverpool
Good opening goal for the reds but United hit back on one of their many counter-attacks. Finely poised, as they say.
48' Marcus Rashford makes it 2-1.
Liverpool concede possession - ball forward completely missed by Rhys Williams and Rashford pushes in.
58' Ball finds its way to Milner inside the area, a good run by the midfielder, and he fires just over the bar.
59' And this time it is in the back of the net.
United try to play out the back but Liverpool get it back, Firmino, to Milner, and a Salah finish!
61' Salah passes out wide to Trent who smashes that one straight at Dean Henderson.
Liverpool have upped their game here.
62' Sadio Mane on to replace Gini Wijnaldum.
Curtis Jones moves back into the middle.
65' Van de Beek and Greenwood off. On comes Fred and Bruno Fernandes.
What time will he get his penalty?
68' Firmino purring in this second half it seems and now Salah is through on goal - saved.
Thought that was going to be his hat-trick.
70' Strong tackle from Mane on Fred. Given a yellow card but he won the ball.
75' All three front players are quite tight. Doesn't give Salah a lot of alternatives so he goes for goal.
Henderson gets that one - not a lot of room for Salah to get any backswing on his shot.
78' Man United awarded a free kick at the edge of the area. It wasn't a free kick.
And Fernandes puts it in the net.
81' Thiago and Firmino make way for Origi and Shaqiri.
86' Martial replaces Rashford for these final few minutes.
89' Cavani heads it down - Alisson watches and it hits the post!
That could have sealed it.
90+2' Liverpool free kick after Pogba gets a yellow card for bringing down Jones.
Comes out to Salah but his volley goes wide.
Man United 2-3 Liverpool
Plenty of good play from Liverpool but the reds were ultimately beaten by a Bruno Fernandes free kick.
Another domestic cup exit for Klopp.
A mistake by Rhys Williams will get highlighted but to blame him is unfair. He’s a young lad who would never have imagined being in this position. The people who run Liverpool knew in November how the manager needed a central defender. Until it’s addressed, there’ll be more bumps— Dominic King (@DominicKing_DM) January 24, 2021
So it's Man United who get another home game - this time against West Ham.
Liverpool travel to Tottenham on Thursday once again with their makeshift defence. How will we get on?
League Table could look a lot worse before that game kicks off too.
Transfer window is slowly closing and Liverpool's failure to replace Gomez, van Dijk, Lovren and a barely fit Joel Matip may need to be acted upon.