Joel Matip makes his first Premier League start for Liverpool FC, whilst Coutinho recovers from a knock that kept him out of the midweek cup game.
Sadio Mane was absent from last week's Burnley game but returned in impressive form in midweek - he too is involved.
Marko Grujic, Daniel Sturridge and Lucas Leiva are amongst those making the bench.
LFC Team: Mignolet, Clyne, Matip, Lovren, Milner, Henderson, Wijnaldum, Lallana, Mane, Coutinho, Firmino
Subs: Manninger, Grujic, Moreno, Lucas, Sturridge, Origi, Stewart
Spurs will be looking to build on their 4 points from their first two games.
Team: Vorm, Walker, Alderweireld, Vertonghen, Rose; Dier, Wanyama, Eriksen, Alli, Lamela; Kane (c)
Subs: McGee, Carter-Vickers, Davies, Onomah, Winks, Janssen, Son