Liverpool have moved to the top of Group E after defeating Racing Genk at Anfield.
The reds should have been clear by half-time but spurned a number of chances throughout the game against a Belgian side who will now have to try and aim for Europa League football.
Klopp rested some players on the bench, and was without Jordan Henderson who was suffering with illness.
However, Fabinho was restored to the Liverpool line up after being rested for the last two fixtures.
The Liverpool boss kept Salah in his starting line up, but Firmino and Mane were replaced in the eleven by Divock Origi and Alex Oxlade-Chamberlain. Origi playing against his schoolboy club of 9 years, while it was more game time for the rapidly rehabilitating Englishman.
Joe Gomez and James Milner were named in the starting line-up, reprising their defensive duties from last week's League Cup game.
Wijnaldum and Keita joined Fabinho in the middle with Oxlade-Chamberlain occupying the role usually filled by Bobby Firmino.
It was Wijnaldum who put the reds ahead after 14 minutes.
Origi and Milner combining neatly on the left wing, and Milly fired a low cross towards the edge of the 6 yard box. The ball cannoned off the Genk defender and instinctively Wijnaldum stroked the ball with the outside of his right boot into the roof of the net.
Salah and Origi had further chances in the first half but with five minutes to go it was the reds who took their foot of the gas.
Samatta earned the visitors a corner, and from the subsequent set-piece he arrived at the near post to power a bullet header past Brazilian Alisson Becker.
The reds had more chances throughout the second half but it was just 8 minutes in when Oxlade-Chamberlain scored what would ultimately prove to be the winner.
Fabinho darted in to win back the ball at the edge of the area and from there Salah played a short pass inside a congested penalty area.
But Alex Oxlade-Chamberlain spun with the ball and aimed perfectly for the bottom corner. A fourth goal in four games for the man originally brought to Anfield to provide cover for the soon to be departed Coutinho.
He is now pushing Sadio Mane in terms of goalscoring strike rate this season.
Sadio Mane, Andy Robertson and Roberto Firmino all came on as the game reached its climax. Getting a few minutes in their legs ahead of the weekends clash with Man City.
The result puts Liverpool into first place in the group, and it means that Liverpool can not just secure qualification, but also secure finishing top if they beat Napoli at Anfield in the next game.
If they can manage that they could enjoy the luxury of some serious rest for many first team players in the final group stage game away at Salzburg.