Liverpool 2-3 Udinese
A double substitution, bringing on Suarez and Gerrard, didn't help Liverpool who shipped two goals in quick succession - losing their third consecutive game at Anfield.
The reds utilised some of the players on the fringe of the squad, while ensuring there was sufficient talent on the bench just in case. However some defensive errors allowed Udinese to take all 3 Europa League points.
Liverpool had plenty of possession at times, particularly the first half, but yet again failed to create enough solid chances to ensure they deserved all three points. Brendan Rodgers complained after the game that in the second half Liverpool switched off, and were lazy - tough words on the players he has so far been keen to praise for their strong work ethic.
After a bright end to end start that saw Reina called in to make a couple of important saves, the reds eventually settled the better. Joe Allen and Jordan Henderson working well together to control the reds midfield as Liverpool saw huge amounts of possession.
Stewart Downing was involved in the goal - getting a rare assist when he fired in a cross from the right wing. Jonjo Shelvey's powerful run saw him arrive in the box and he headed downwards to open the scoring. His celebration - consisting of a faux two footed challenge and mimicking spectacles - suggested that his ongoing league ban thanks to Mark Halsey is still smarting.
30 seconds in to the second half Antonio Di Natale scored the equaliser. It was Glen Johnson who was caught in possession and Lazzari and Di Natale exchanged some touches of the ball before Di Natale clipped it past Reina.
Gerrard and Suarez were sent on for the promising Assaidi and Henderson and within minutes the reds found themselves 3-1 down.
Udinese's second came from a deep lying cross - Carragher forced Coates further back and the Uruguayan headed in to his own net. It was a shambolic piece of defending but the reds had not dealt well with set pieces in to the box all night.
The Italian's third goal even saw Di Natale spending time in the Liverpool box doing some keepy-ups before setting up Pasquale who fired in a powerful shot.
Luis Suarez scored a consolation goal for the reds but it was all too little too late.
The reds lie 3rd in the group after two games - far more worrying will be the 6 goals conceded by Liverpool in those opening two games. The reds return to Anfield on Sunday for a Premier League clash against Stoke. Rodgers will be hoping the defence allow the team the opportunity to end their Anfield losing streak.