Ben Woodburn became Liverpool's youngest ever goalscorer as the reds marched to the League Cup semi finals, again.
Jurgen Klopp made 8 changes from Saturday's starting line-up with three of them enforced.
Coutinho will be out for over a month, whilst both Firmino and Matip picked up knocks in the weekend's win over Sunderland.
However, compared to the previous League Cup game against Tottenham there were just 2 LFC changes. Mane in for Sturridge (injured) and Can in for Grujic - Marko Grujic has also been struggling with a knock in recent weeks.
Klopp kept faith with Kevin Stewart, Ovie Ejaria and Trent Alexander-Arnold in his 'League Cup team'.
Leeds made 5 changes from their team that started and won in the Championship on Saturday.
Lucas named Captain
Lucas Leiva was named as Liverpool captain - and he was the focus of the TV cameras as both sides participated in a pre-match minutes silence held just hours after the Colombian air disaster which killed a large number of players and staff of the Brazilian football side Chapecoense.
Leeds make bright start
Leeds are doing well in the Championship - currently 5th and attempting to reach their highest position in the Championship for 11 years.
And they started in confident mood at Anfield backed by over 5,000 of their travelling support. Leeds last visit to Anfield was 13 years ago so for many young men and women this will have been their first visit to the stadium.
Hadi Sacko gave Simon Mignolet something to do in the opening minutes - the Belgian keeper forced to tip wide for a corner.
It was 12 minutes before the reds got their first shot away - and it was Gini Wijnaldum, who was playing in a more advanced position than usual, that forced the save.
Ragnar Klavan may recently have been awarded the Estonian Player of the Year (again) but his shot on the quarter hour mark reminded us all why he plays in defence. It went well wide.
A Leeds defensive mix up on the half hour allowed Emre Can to get a faint toe poke at the ball - it agonisingly went wide of the open goal.
The reds ended the first half on the back foot, and Leeds came out at the start of the second with continued determination.
Placing the reds under pressure they fired a chance that rebounded off the post around a stranded Simon Mignolet but was fortunately cleared by the reds.
Reds substitution changes momentum
Liverpool brought on 17 year old Ben Woodburn and the change sparked some life into the reds as the minutes ticked down towards an expectant extra time.
But extra time wasn't going to be happening tonight.
A wonderful cross from the impressive Alexander-Arnold headed into the danger zone and Divock Origi stretched to dispatch the ball into the net. 1-0.
Shortly after it looked like Origi would be leaving the field through injury but he stayed on, and it was a good job he did. He supplied the initial pass across the penalty area that fed Ben Woodburn, who fired powerfully into the net in front of The Kop to make it 2-0 AND become Liverpool's youngster ever goalscorer.
He beats previous holder of that honour, Michael Owen, by being 3 months younger.
The final 10 minutes were played out in some comfort for Liverpool who march into the semi-finals of the League Cup for the 4th time in 6 years.